The expanded CAG repeats not only affect the huntingtin protein - they affect DNA replication itself.

多余的CAG序列不仅影响huntingtin蛋白，也影响了DNA本身的复制。

CAG codes for the amino acid glutamine, so people with Huntington disease patients will have 36 or more glutamines in a row in the huntingtin protein.

因为CAG序列对应的是谷氨酰胺（氨基酸），所以在HD患者体内，huntingtin蛋白质上会有36个以上连续的谷氨酰胺。

In most people, a gene called huntingtin or HTT on chromosome 4, contains a triplet repeat, where the nucleotides C, A, and G are repeated 10-35 times in a row.

大多数人体内，位于4号染色体上的HTT基因，有一段三核苷酸重复序列，即核苷酸CAG，连续重复拷贝10-35次。