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单词 Holliday junction
释义

Holliday junction

中文百科

霍利迪交叉

Holliday交叉图解。
Holliday交叉的分子结构。来源：PDB 3CRX。
Schematic of a Holliday Junction showing the base sequence and secondary structure but not the tertiary structure. The sequence shown is only one of many possibilities. This is an immobile Holliday junction because the sequences are not symmetrical.
Molecular structure of a stacked Holliday junction, in which the four arms stack into two double-helical domains. Note how the blue and red strands remain roughly helical, while the green and yellow strands cross over between the two domains.Molecular structure of an unstacked Holliday junction. This conformation lacks base stacking between the double-helical domains, and is stable only in solutions lacking divalent metal ions such as Mg2+. From PDB: 3CRX 3CRX​.

Holliday交叉（Holliday junction）是四股DNA所形成的交叉结构，名称来自此于1964年提出此概念者Robin Holliday，用以解释发现于酵母菌的遗传信息交换，也就是同源重组。目前遗传学上所知的Holliday交叉结构已经过修正，与当初提出时有所不同，但仍然使用原来的名称。

英语百科

Holliday junction 霍利迪交叉

Schematic of a Holliday Junction showing the base sequence and secondary structure but not the tertiary structure. The sequence shown is only one of many possibilities. This is an immobile Holliday junction because the sequences are not symmetrical.
Molecular structure of a stacked Holliday junction, in which the four arms stack into two double-helical domains. Note how the blue and red strands remain roughly helical, while the green and yellow strands cross over between the two domains.Molecular structure of an unstacked Holliday junction. This conformation lacks base stacking between the double-helical domains, and is stable only in solutions lacking divalent metal ions such as Mg2+. From PDB: 3CRX 3CRX​.
Schematic diagrams of the three base-stacking conformational isomers of the Holliday junction. The two stacked conformers differ in which sets of two arms are bound by coaxial stacking: at left, the stacks are red–blue and cyan–magenta, while at right the stacks are red–cyan and blue–magenta. The bases nearest to the junction point determine which stacked isomer dominates.

A Holliday junction is a branched nucleic acid structure that contains four double-stranded arms joined together. These arms may adopt one of several conformations depending on buffer salt concentrations and the sequence of nucleobases closest to the junction. The structure is named after the molecular biologist Robin Holliday, who proposed its existence in 1964.
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更新时间：2025/6/19 4:50:13