The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
Histone deacetylase
英语例句库
中文百科
组蛋白脱乙酰酶
组蛋白脱乙酰酶类（英语：Histone deacetylases，EC3.5.1.98，简称为HDAC）是能将组蛋白赖氨酸上ε-N-乙酰基（O=C-CH3）水解掉的一类酶，这使得DNA缠绕组蛋白更加紧密。这点非常重要，因为DNA缠绕着组蛋白，而DNA的表达水平受到组蛋白乙酰化与脱乙酰化水平的影响。该酶的作用与组蛋白乙酰转移酶对冲。HDAC蛋白现在亦被称为赖氨酸脱乙酰酶类（KDAC），这样做的目的是为了突出其功能而非其靶点，因其作用靶点亦包括了非组蛋白的蛋白质类。
英语百科
Histone deacetylase 组蛋白脱乙酰酶
Histone deacetylases (EC3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
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