Histone acetyltransferase

（重定向自Histone acetylation）

Relative sizes and locations of important domains for representative HATs (HAT = catalytic acetyltransferase domain; Bromo = bromodomain; Chromo = chromodomain; Zn = zinc finger domain). The number of amino acid residues in each HAT is indicated at the right in each example.

Crystal structure of Tetrahymena Gcn5 with bound coenzyme A and histone H3 peptide (PDB 1QSN). The central core (green), flanking N- and C-terminal segments (blue), coenzyme A (orange), and histone peptide (red) are shown.

Catalytic mechanisms of GNAT and MYST family HATs. (A) General mechanism of GNAT HATs. (B) General mechanism of MYST HATs.

Schematic showing the role of HATs in gene transcription.

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

单词	Histone acetylation
释义	Histone acetylation 英语百科 Histone acetyltransferase （重定向自Histone acetylation） Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.
随便看	hexagonal prism of the first order的意思 hexagonal prism of the second order的意思 hexagonal prism of the third order的意思 hexagonal prisms的意思 hexagonal propelling pencil的意思 Hexagonal pyramid的意思 hexagonal pyramidal class的意思 hexagonal pyramidal hemihedral class的意思 hexagonal pyramidal hemimorphic class的意思 hexagonal pyramid of second order的意思 hexagonal pyramid of the first order的意思 hexagonal pyramid of the second order的意思 hexagonal pyramid of the third order的意思 hexagonal pyramid of third order的意思 hexagonal rhobohedral tetartohedral class的意思 hexagonal rhombohedral hemibedral class的意思 hexagonal rhombohedral hemihedral class的意思 hexagonal rhombohedral hemimorphic class的意思 hexagonal rhombohedral tetartohedral class的意思 hexagonal rod的意思 hexagon的意思 hexagonal safety set screw的意思 Hexagonal sampling的意思 hexagonal scalenohedral class的意思 hexagonal scalenohedron的意思