Hexosaminidase
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![Hydrolysis of GM2 ganglioside to GM3 ganglioside catalyzed by hexosaminidase A.[8]The mechanism of the hydrolysis of a GM2 ganglioside and removal of a GalNAc residue to produce GM3 ganglioside.[8]](/uploads/202501/18/Gangs_Mechanism1441.jpg)
![The alpha subunit active site shown bound to NAG-thiazoline (NGT) in beta-hexosaminidase. PDB: 2GK1 The light green outline surrounding NGT represents the Van der Waals surface of NGT. The critical amino acids in the active site that are able to hydrogen bond with NGT include Arginine 178 and Glutamate 462.[8]The beta subunit active site shown bound to NAG-thiazoline (NGT) in beta-hexosaminidase. PDB: 2GK1 The light blue outline surrounding NGT represents the Van der Waals surface of NGT. The critical amino acids in the active site that are able to hydrogen bond with NGT include Glutamate 491 and Aspartate 452.[8]](/uploads/202501/18/Final_Alpha_Active_Site1441.jpg)
Hexosaminidase (EC3.2.1.52, beta-acetylaminodeoxyhexosidase, N-acetyl-beta-D-hexosaminidase, N-acetyl-beta-hexosaminidase, N-acetyl hexosaminidase, beta-hexosaminidase, beta-acetylhexosaminidinase, beta-D-N-acetylhexosaminidase, beta-N-acetyl-D-hexosaminidase, beta-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, beta-D-hexosaminidase) is an enzyme involved in the hydrolysis of terminal N-acetyl-D-hexosamine residues in N-acetyl-β-D-hexosaminides.