Orotic aciduria

Orotic aciduria refers to an excessive excretion of orotic acid in urine. It causes a characteristic form of anemia and may be associated with mental and physical retardation.

Orotic acid is an intermediate product in pyrimidine synthesis pathway, a subsequent product of which plays a role in conversion between dihydrofolate and tetrahydrofolate. Orotic aciduria is associated with megaloblastic anemia due to decreased pyrimidine synthesis, which leads to decreased nucleotide-lipid cofactors needed for erythrocyte membrane synthesis in the bone marrow.

单词	Hereditary orotic aciduria
释义	Hereditary orotic aciduria 英语百科 Orotic aciduria Orotic aciduria refers to an excessive excretion of orotic acid in urine. It causes a characteristic form of anemia and may be associated with mental and physical retardation. Orotic acid is an intermediate product in pyrimidine synthesis pathway, a subsequent product of which plays a role in conversion between dihydrofolate and tetrahydrofolate. Orotic aciduria is associated with megaloblastic anemia due to decreased pyrimidine synthesis, which leads to decreased nucleotide-lipid cofactors needed for erythrocyte membrane synthesis in the bone marrow.
随便看	methyl coniine的意思 methylconiine的意思 methylcortisol的意思 methyl corypalline的意思 methylcorypalline的意思 methylcoumarin的意思 methylcoumarone的意思 methylcoumestrol的意思 methyl CpG binding protein的意思 methylcphedrine的意思 methylcreosol的意思 methyl cresol的意思 methylcrotonate的意思 methyl crotonate的意思 methyl crotonic acid的意思 methylcrotonic acid的意思 Methylcrotonic aciduria的意思 methylcrotonoyl CoA carboxylase的意思 methylcrotonyl CoA的意思 Methylcrotonyl CoA carboxylase deficiency的意思 Methylcrotonylglycinuria的意思 methylcumarone的意思 methylcurine的意思 methyl cyanacetate的意思 methylcyanacetate的意思

Hereditary orotic aciduria

Orotic aciduria