肝硬化（德语：Zirrhose，西班牙语：cirrosis，英语：cirrhosis，英语发音：/sɪˈroʊsɪs/）指的是肝脏因长期受到伤害，导致最后无法正常运作。肝硬化是漫长的过程，在早期通常没有症状，随着疾病的发展，患者可能开始感到容易疲倦、虚弱、下肢水肿、皮肤泛黄、容易瘀青、产生腹水、或是在皮肤上见到如蜘蛛般延展的血管等等。腹水一旦发生就可能发生自发性细菌腹膜炎。其他与肝硬化相关的疾病与症状还有肝性脑病变、由于曲张的食道静脉破裂而造成的吐血、肝肾综合症、以及肝癌等。肝脑病变可能造成患者意识混乱甚至陷入昏迷。

Cirrhosis is a condition in which the liver does not function properly due to long-term damage. Typically, the disease comes on slowly over months or years. Early on, there are often no symptoms. As the disease worsens, a person may become tired, weak, itchy, have swelling in the lower legs, develop yellow skin, bruise easily, have fluid build up in the abdomen, or develop spider-like blood vessels on the skin. The fluid build-up in the abdomen may become spontaneously infected. Other complications include hepatic encephalopathy, bleeding from dilated veins in the esophagus or dilated stomach veins, and liver cancer. Hepatic encephalopathy results in confusion and possibly unconsciousness.