Harlequin-type ichthyosis

Harlequin-type ichthyosis (also known as harlequin baby, harlequin ichthyosis, hyosis fetalis, keratosis diffusa fetalis, harlequin fetus, and ichthyosis congenita gravior), is a severe genetic skin disease, which causes thickening of the stratum corneum of the epidermis. At birth, the child’s whole body is encased in an 'armour' of thick white plates of skin, separated with deep cracks. In addition, the eyes, ears, penis, and the appendages may be abnormally contracted. Because of resultant cracked skin in locations where normal skin would fold, it is easily pregnable by bacteria and other contaminants, which can result in serious risk of fatal infection. Constant care is required to moisturise and protect the skin.