牛肝菌科（学名：Boletaceae）是担子菌门下伞菌目的一科。担子果肉质，孔状。约50余种，很多种可食用。世界性分布，在湿热带雨季常见于林中。

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The Boletaceae are a family of mushrooms, primarily characterized by developing their spores in small pores on the underside of the mushroom, instead of gills, as are found in agarics. Nearly as widely distributed as agarics, they include the Cep or King Bolete (Boletus e****s), much sought after by mushroom hunters. As a whole, the typical members of the family are commonly known as boletes.