Guarambaré is a town in the Central Department of Paraguay. Guarambaré was the name of a Guaraní tribe in North-Eastern Paraguay at the time of the founding of the Spanish colony during the 16th century. A Franciscan reduction was founded between 1580 and 1600 in the modern day department of Concepción, south of the river Aquidabán. The reduction was relocated in 1673 to the current location, south-east of Asunción.