瓜达尔基维尔河（西班牙语：Guadalquivir）是西班牙的第五长河（仅次于塔古斯河和埃布罗河），也是安达卢西亚自治区境内的第一长河。它的名字源于阿拉伯语阿尔-瓦德-阿尔-卡比尔（الوادي الكبير‎，音译al-Wadī al-Kabīr），意为“大河”。在阿拉伯人征服之前，这条河的名字是巴埃提斯河，罗马帝国在西班牙的行省巴埃提卡行省即以此河命名。

瓜达尔基维尔河全长657公里，流域面积约58，000平方公里。它发源于哈恩省境内的卡索拉山脉，流经科尔多瓦和塞维利亚两大城市，在桑卢卡尔-德巴拉梅达附近的小渔村注入加的斯湾。河流入海口处的湿地构成了多尼安纳国家公园自然保护区。

The Guadalquivir (Spanish pronunciation: [ɡwaðalkiˈβir]) is the fifth longest river in the Iberian peninsula and the second longest river with its entire length in Spain. The Guadalquivir is 657 kilometers, (408 miles) long and drains an area of about 58,000 square kilometers. It begins at Cañada de las Fuentes (village of Quesada) in the Cazorla mountain range (Jaén), passes through Córdoba and Seville and ends at the fishing village of Bonanza, in Sanlúcar de Barrameda, flowing into the Gulf of Cádiz, in the Atlantic Ocean. The marshy lowlands at the river's end are known as "Las Marismas". It borders Doñana National Park reserve.