大圣伯纳德山口 （德语：Grosser Sankt Bernhard；法语：Col du Grand-Saint-Bernard；意大利语：Gran San Bernardo）是迄今最古老的跨越西阿尔卑斯山的山口，那里目前仍然能够看到上溯至青铜时代的人类活动遗迹、罗马时代的羊肠小道和拿破仑军队1800年进入意大利时使用的道路。山口处一所始建于1049年的旅舍目前仍在接待游客，旅舍以马松的圣伯纳德（Saint Bernard of Menthon）命名，包括两幢分别于1560年和1898年建造的房屋（如右图）。1923年，罗马教宗庇护十一世确认伯纳德为“守护阿尔卑斯山的圣徒”（Patron Saint of the Alps）。

Great St. Bernard Pass (Fr. Col du Grand-Saint-Bernard, It. Colle del Gran San Bernardo) (el. 2469 m.) is the third highest road pass in Switzerland. It connects Martigny in the Canton of Valais in Switzerland to Aosta in Italy. It is the lowest pass lying on the ridge between the two highest summits of the Alps, Mont Blanc and Monte Rosa. The pass itself is located in Switzerland in the canton of Valais, very close to Italy. It is located on the main watershed that separates the basin of the Rhône from that of the Po.