满垒全垒打（英语：grand slam），或称满贯全垒打、满垒打，指打者在满垒时（也就是一垒、二垒、三垒都有跑者）打出的全垒打，可一口气得到4分。1999年美国职棒大联盟洛杉矶道奇投手朴赞浩出战红雀队，遭到当时红雀三垒手大帝士（Fernando Tatis）单局击出两支满贯全垒打，成为美国大联盟的百年记录。

场内大满贯（inside-the-park grand slam）需兼具两者的特性，非常罕见。美国职棒大联盟最近一次出现场内大满贯是在1999年10月3日由坦帕湾魔鬼鱼队的Randy Winn所击出的。

In baseball, a grand slam is a home run hit with all three bases occupied by baserunners ("bases loaded"), thereby scoring four runs—the most possible in one play. According to The Dickson Baseball Dictionary, the term originated in the card game of contract bridge, in which a grand slam involves taking all the possible tricks. The word slam, by itself, usually is connected with a loud sound, particularly of a door being closed with excess force; thus, slamming the door on one's opponent(s), in addition to of course the bat slamming the ball into a home run. The term was extended to various sports, such as golf and tennis, for sweeping a sport's major tournaments.