Glutamate–cysteine ligase
(重定向自Glutamate cysteine ligase)
Glutamate Cysteine Ligase (GCL) (EC6.3.2.2), previously known as gamma-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic pathway that catalyzes the chemical reaction:
L-glutamate + L-cysteine + ATP gamma-glutamyl cysteine + ADP + Pi