格拉泽偶联反应（Glaser coupling），以研究者卡尔·格拉泽的名字命名。

两分子末炔在碱和铜盐作用下，偶联为双炔。此反应是最古老的炔偶联反应。

一价铜盐为反应所必需，常见的是氯化亚铜、溴化亚铜和乙酸亚铜。氨是经典的所用碱，用于夺取炔的酸性CH质子。溶剂可以是水或乙醇。反应经双核的、含桥连的炔配体的铜络合物中间体。 氧气用于铜催化剂的重新氧化。

The Glaser coupling is a type of coupling reaction. It is by far the oldest acetylenic coupling and is based on cuprous salts like copper(I) chloride or copper(I) bromide and an additional oxidant like oxygen. The base in its original scope is ammonia. The solvent is water or an alcohol. The reaction was first reported by Carl Andreas Glaser in 1869.