Antifolate

（重定向自Folic acid antagonists）

Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B₉).<ref name=" Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).

单词	Folic acid antagonists
释义	Folic acid antagonists 英语百科 Antifolate （重定向自Folic acid antagonists） Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B₉).<ref name=" Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).
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