局灶节段性肾小球硬化症(Focal segmental glomerulosclerosis、FSGS、局灶节段性肾丝球硬化症)是小孩和青少年肾病综合征的原因，以及成年人肾功能衰竭的重要原因。 它也被称为"局灶肾小球硬化"(focal glomerular sclerosis)或"局灶结节性肾小球硬化"(focal nodular glomerulosclerosis)。 它约占肾病综合征病例的六分之一。 (微小病变(MCD)是迄今为止肾病综合征小孩病患最常见的原因：MCD与原发性FSGS可能有类似的原因。)

Focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in children and adolescents, as well as a leading cause of kidney failure in adults. It is also known as "focal glomerular sclerosis" or "focal nodular glomerulosclerosis." It accounts for about a sixth of the cases of nephrotic syndrome. (Minimal change disease (MCD) is by far the most common cause of nephrotic syndrome in children: MCD and primary FSGS may have a similar cause.)