The factor V degradation product also binds to this complex and further enhances its ability to cleave more active factor V and active factor VIII.

V因子的分解产物也结合到复合物上，进一步增强了裂解更多活跃的V因子和VIII因子的能力。

So, in people with protein C and S deficiency, the thrombin-thrombomodulin complex can't cleave and inactivate factors V and VIII.

所以，在蛋白C和S缺乏症患者体内，凝血酶-血栓调节蛋白复合物不能裂解灭活V因子和VIII因子。

This increases circulating factor V and factor VIII levels, and " tips the scale" toward coagulation, putting them at increased risk for thrombosis, or developing blood clots.

这使得血液循环中V因子和VIII因子数量增多，更容易发生凝血，导致血栓形成的风险增加。

All right, as a quick recap, protein C and S deficiency refer to two separate hereditary hypercoagulable disorders that involve the inability to inactivate factors V and VIII in the coagulation cascade.

得！快速复习一下：蛋白C和蛋白S缺乏症是指两种独立的遗传性血液高凝功能障碍，涉及在凝血过程中无法使V因子及Ⅷ因子失活。