Fabriano is a town and comune of Ancona province in the Italian region of the Marche, at 325 metres (1,066 ft) above sea level. It lies in the Esino valley 44 kilometres (27 mi) upstream and southwest of Jesi; and 15 kilometres (9 mi) east-northeast of Fossato di Vico and 36 kilometres (22 mi) east of Gubbio (both in Umbria). Its location on the main highway and rail line from Umbria to the Adriatic make it a mid-sized regional center in the Apennines. Fabriano is the headquarters of the giant appliance maker Indesit.