PAX6

Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. Pax6 is a transcription factor present during embryonic development. The encoded protein contains two different binding sites that are known to bind DNA and function as regulators of gene transcription. It is a key regulatory gene of eye and brain development. Within the brain, the protein is involved in development of the specialized cells that process smell. As a transcription factor, Pax6 activates and/or deactivates gene expression patterns to ensure for proper development of the tissue. Mutations of the Pax6 gene are known to cause various disorders of the eyes. Two common disorders associated with a mutation are: aniridia, the absence of the iris, and Peter's anomaly, thinning and clouding of the cornea. Scientists have created a "tae" model using mice during which time the mouse does not express Pax6. The "knockout" model is eyeless or has very underdeveloped eyes further indicating Pax6 is required for proper eye development.

单词	eyeless
释义	eyeless /'aɪlɪs/ 英汉-汉英词典 adj. 盲目的；无眼的；瞎的词组 \| 习惯用语您要查找的是不是： eyelash n. 睫毛 eyeglass n. 眼镜；镜片 eyelets n. 孔眼（eyelet的复数） v. 在…上打小孔（eyelet的第三人称单数）网络短语: eyeless five 盲眼老五 eyeless sight 非目视视觉 Eyeless Skull 无眼头颅 Eyeless fetus 无眼畸胎 eyeless suture needle 无损伤缝合针 eyeless in gaza 加沙的盲人；表演者 blindfold eyeless sightless 盲目的 eyeless s suture needle 无损伤缝合针 Wall of the Eyeless 无眼之墙原声例句戏剧速成小课堂 Louise stands up long enough for the audience to see her mutilated eyeless face and then dies. 露易丝站了很长时间让观众看到她那残缺不全的没有眼睛的脸然后挂了。美丽新世界 After that the skeleton. At seventy per cent of normal oxygen you got dwarfs. At less than seventy eyeless monsters. 然后是骨骼。供氧量只达正常量百分之七十就形成侏儒。低于百分之七十就成了没有眼睛的怪胎。” TED-Ed（视频版） When the resulting offspring hatch, they bear little resemblance to their parents; they're smaller, wingless, eyeless, and sterile. 当由此产生的后代孵化时，它们与父母几乎没有相似之处；它们更小，没有翅膀，没有眼睛，而且不育。哈利波特与凤凰社 The Dementor's eyeless face was barely an inch from Dudley's when the silver antlers caught it; the thing was thrown up into the air and, like its fellow, it soared away and was absorbed into the darkness. 摄魂怪那没有眼睛的脸离达力的脸只差不到一英寸了，说时迟那时快，银色的鹿角刺中了它，把它挑起来抛到半空。它像刚才它的那个同伴一样，腾空逃走，被黑暗吞没了。 2013 English Cafe There are a few types of what are called " blind fish" or eyeless fish – fish that don't have any eyes – I suppose because it's so dark in the cave, they didn't need eyes. 有几种所谓的“盲鱼”或无眼鱼——没有眼睛的鱼——我想是因为洞里太黑了，它们不需要眼睛。英语百科 PAX6 Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. Pax6 is a transcription factor present during embryonic development. The encoded protein contains two different binding sites that are known to bind DNA and function as regulators of gene transcription. It is a key regulatory gene of eye and brain development. Within the brain, the protein is involved in development of the specialized cells that process smell. As a transcription factor, Pax6 activates and/or deactivates gene expression patterns to ensure for proper development of the tissue. Mutations of the Pax6 gene are known to cause various disorders of the eyes. Two common disorders associated with a mutation are: aniridia, the absence of the iris, and Peter's anomaly, thinning and clouding of the cornea. Scientists have created a "tae" model using mice during which time the mouse does not express Pax6. The "knockout" model is eyeless or has very underdeveloped eyes further indicating Pax6 is required for proper eye development. 近义、反义、联想词近义词 adj. blind, unsighted 反义词 n. eyed, sighted 联想词 humanoid像人的;blind瞎的;mutant突变体;hooded有罩盖的，戴头巾的;faceless无个性的;ghostly幽灵的;eyes眼睛;bearded有芒的;grotesque奇形怪状的;corpse尸体;octopus章鱼; 英英词典 eyeless adj. lacking eyes or eyelike features eyeless fish that evolved in dark caves an eyeless needle lacking sight blind as an eyeless beggar synonymous： sightless, unseeing
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eyeless /'aɪlɪs/

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PAX6

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