季节性脱皮，医学上叫做剥脱性角质松解症，指受季节和天气变化引起的手脚脱皮。大多发生在天气变化剧烈和季节交替的时间，所以称为季节性脱皮。季节性手脚脱皮一般发生在春季和秋季，以5月份和11月份为最严重的季节。非真菌引起，需和手癣脚癣相区别。

这种脱皮是不影响身体健康的生理现象，患者不必有过度精神紧张心理。

季节性手脱皮成因复杂，很难根治，具有双手对称性，无菌性的特点。可适当补充维生素来治疗。

Keratolysis exfoliativa, (also known as "Lamellar dyshidrosis,", "Recurrent focal palmar peeling," "Recurrent palmar peeling") is a sometimes harmless, sometimes painful skin condition that can affect the focal surface of the fingers and/or the palm or soles of the feet. It is often misdiagnosed as chronic contact dermatitis or psoriasis. It is characterized by dry skin and superficial, air-filled blisters. These blisters can be peeled off very easily and will leave reddish, tender areas. The loss of this horny layer of the skin, which protects the underlying layers, leaves the skin more vulnerable to dryness and cracking.