Espiritu Santo is the largest island in the nation of Vanuatu, with an area of 3,955.5 km (1,527.2 sq mi) and a population of around 40,000 according to the 2009 census.

It belongs to the archipelago of the New Hebrides in the Pacific region of Melanesia. It is in the Sanma Province of Vanuatu. The town of Luganville, on Espiritu Santo's southeast coast, is Vanuatu's second-largest settlement and the provincial capital. Roads run north and west from Luganville but most of the island is far from the limited road network.