Epibatidine

Epibatidine is an alkaloid that is secreted by the Ecuadoran frog Epipedobates anthonyi. It was discovered by John W. Daly in 1974, but its structure was not fully elucidated until 1992.

Epibatidine is toxic. Its toxicity stems from its ability to interact with nicotinic and muscarinic acetylcholine receptors. These receptors are involved in the transmission of painful sensations, and in movement, among other functions. Epibatidine then causes numbness and eventually paralysis. Doses are lethal when the paralysis causes respiratory arrest. Originally, it was thought that epibatidine could be useful as a drug. However, because it can be deadly even at very low doses, it is no longer being researched for potential therapeutic uses.

单词	Epibatidine
释义	Epibatidine 原声例句 TED-Ed（视频版） One of their most potent alkaloids is the chemical epibatidine, which binds to the same receptors in the brain as nicotine but is at least ten times stronger. 他们最有效的生物碱之一是化学 epibatidine，它与大脑中与尼古丁相同的受体结合，但至少强十倍。英语百科 Epibatidine Epibatidine is an alkaloid that is secreted by the Ecuadoran frog Epipedobates anthonyi. It was discovered by John W. Daly in 1974, but its structure was not fully elucidated until 1992. Epibatidine is toxic. Its toxicity stems from its ability to interact with nicotinic and muscarinic acetylcholine receptors. These receptors are involved in the transmission of painful sensations, and in movement, among other functions. Epibatidine then causes numbness and eventually paralysis. Doses are lethal when the paralysis causes respiratory arrest. Originally, it was thought that epibatidine could be useful as a drug. However, because it can be deadly even at very low doses, it is no longer being researched for potential therapeutic uses.
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