美国国家环境保护局（英语：Environmental Protection Agency，缩写：EPA），常简称美国环保署，是美国联邦政府的一个独立行政机构，主要负责维护自然环境和保护人类健康不受环境危害影响。EPA由美国总统尼克松提议设立，在获国会批准后于1970年12月2日成立并开始运行。在环保局成立之前，联邦政府没有组织机构可以共同合协地对付危害人体健康及破坏环境的污染物问题。环保局局长由美国总统直接指认，直接向美国白宫问责。EPA不在内阁之列，但于内阁各部门同级，现任局长为吉娜·麦肯锡（Gina McCarthy）。EPA现有大约18,000名全职雇员，所辖机构包括华盛顿总局、10个区域分局、和超过17个研究实验所。

The United States Environmental Protection Agency (EPA or sometimes USEPA) is an agency of the U.S. federal government which was created for the purpose of protecting human health and the environment by writing and enforcing regulations based on laws passed by Congress. The EPA was proposed by President Richard Nixon and began operation on December 2, 1970, after Nixon signed an executive order. The order establishing the EPA was ratified by committee hearings in the House and Senate. The agency is led by its Administrator, who is appointed by the president and approved by Congress. The current administrator is Gina McCarthy. The EPA is not a Cabinet department, but the administrator is normally given cabinet rank.