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单词 Alpha adrenergic receptor
释义

Alpha adrenergic receptor

中文百科

肾上腺素受体 Adrenergic receptor

(重定向自Alpha adrenergic receptor)

肾上腺素能受体英语:Adrenergic receptors,或称为肾上腺素受体)是一类接受儿茶酚胺类物质刺激的代谢型G蛋白偶联受体,所接受的儿茶酚胺类主要是去甲肾上腺素以及肾上腺素。尽管多巴胺也属于儿茶酚胺类,但它的受体属于与此不同的另一类。

英语百科

Adrenergic receptor 肾上腺素受体

(重定向自Alpha adrenergic receptor)
The mechanism of adrenergic receptors. Adrenaline or noradrenaline are receptor ligands to either α1, α2 or β-adrenergic receptors. α1 couples to Gq, which results in increased intracellular Ca2+ and subsequent smooth muscle contraction. α2, on the other hand, couples to Gi, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction. β receptors couple to Gs, and increases intracellular cAMP activity, resulting in e.g. heart muscle contraction, smooth muscle relaxation and glycogenolysis.
Beta-2 adrenergic receptor (PDB: 2rh1​), which stimulates cells to increase energy production and utilization. The membrane is shown schematically with a gray stripe.

The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).

Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle.

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更新时间:2025/6/17 23:38:02