Splenomegaly

（重定向自Enlarged spleen）

Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of hypersplenism which include; some reduction in the number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination, a compensatory proliferative response in the bone marrow, and the potential for correction of these abnormalities by splenectomy. Splenomegaly is usually associated with increased workload (such as in hemolytic anemias), which suggests that it is a response to hyperfunction. It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of an enlarged spleen, along with caput medusa, is an important sign of portal hypertension.

单词	Enlarged spleen
释义	Enlarged spleen 原声例句 WIL生活启示录 The doctors found she had a shrunken liver and an enlarged spleen. 医生发现她的肝脏萎缩，脾脏增大。日常生活医学科普 These disorders can result in: bone deformities; enlarged spleen; heart problems; growth and developmental delays in children. 骨骼畸形；脾脏增大；心脏问题；儿童生长发育迟缓。 Osmosis-消化 So venous blood accumulates downward from the obstruction, causing features like ascites, esophageal varices and bleeding, Caput Medusae, diminished liver function and an enlarged spleen. 因此静脉血从阻塞处向下累积，引起诸如腹水、食管静脉曲张和出血、海蛇头、肝功能下降和脾脏肿大等特征。 Osmosis-消化 Portal hypertension can also cause blood to back up into the spleen causing congestive splenomegaly, meaning the enlarged spleen. 门静脉高压症还能导致血液向脾脏回流，造成充血性脾肿大，即扩大的脾。 Osmosis-血液肿瘤 The excess iron damages multiple organs, which can cause fatigue, heart disease, liver damage, enlarged spleen, kidney failure, and diarrhea. 过量的铁会损害多个器官，导致疲劳、心脏病、肝损伤、脾肿大、肾功能衰竭与腹泻。 Osmosis-消化 The features of portal hypertension can be remembered as ABCDE, where A stands for Ascites, B for Bleeding, C for Caput Medusae, D for Diminished liver function, and E for Enlarged spleen. 门静脉高压症的特点可以用ABCDE来记：A指的是腹水，B是流血，C是海蛇头，D指肝功能下降，E指脾脏肿大。英语百科 Splenomegaly （重定向自Enlarged spleen） Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of hypersplenism which include; some reduction in the number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination, a compensatory proliferative response in the bone marrow, and the potential for correction of these abnormalities by splenectomy. Splenomegaly is usually associated with increased workload (such as in hemolytic anemias), which suggests that it is a response to hyperfunction. It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of an enlarged spleen, along with caput medusa, is an important sign of portal hypertension.
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