Eliprodil

Eliprodil (SL-82.0715) is a NMDA antagonist drug candidate that failed a Phase III clinical trial for the treatment of acute ischemic stroke in 1996, sponsored by Synthélabo Recherche.

NMDA receptors are a key component in mediating glutamate-induced excitotoxicity, and it is believed that NMDA antagonists would be neuroprotective after a stroke or other traumatic brain injury. After a traumatic brain injury, neurons become deprived of glucose and oxygen. These neurons quickly lose ATP and become depolarized, which releases glutamate. The intracellular buildup of glutamate trigger the overstimulation of AMPA and NMDA receptors. This, in turn, causes an influx of Na+ and Ca+. Therefore, when NMDA receptors are activated, there is an increase in intracellular Ca+ concentration. High Ca+ causes fatal metabolic consequences, including neuronal cell death.