东海岸主线（East Coast Main Line）是英国的一条铁路路线，是英国主要铁路干线之一。通称「ECML」。东海岸主线的起点是伦敦的国王十字站，终点是爱丁堡的威瓦利站。这条路线连接了伦敦和约克郡、英格兰东北及苏格兰，是大不列颠岛东部的交通大动脉。东海岸主线的列车的最高时速可以达到125英里（200km）。

The East Coast Main Line (ECML) is a 393-mile long (632 km) railway link between London and Edinburgh via Peterborough, Doncaster, Wakefield, Leeds, York, Darlington and Newcastle, electrified along the whole route. Services north of Edinburgh to Aberdeen and Inverness use diesel trains. The main franchise on the line is operated by Virgin Trains East Coast.