烷化剂 Alkylating antineoplastic agent
（重定向自Alkylating drug）
烷化剂（Alkylating agents，或烷基化剂）是一种有机化合物，能使烷基转移到其他分子上，此过程称为烷基化。
烷化剂具有生物活性，因此可用来当作化学武器，如芥子气。一般也应用于炼油、塑胶或制药工业上。
| 单词 | Alkylating drug |
| 释义 |
Alkylating drug
中文百科
烷化剂 Alkylating antineoplastic agent（重定向自Alkylating drug）
烷化剂（Alkylating agents，或烷基化剂）是一种有机化合物，能使烷基转移到其他分子上，此过程称为烷基化。 烷化剂具有生物活性，因此可用来当作化学武器，如芥子气。一般也应用于炼油、塑胶或制药工业上。
英语百科
Alkylating antineoplastic agent 烷化剂（重定向自Alkylating drug）
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA. The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring. Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage — such as being alkylated. Alkylating agents are used to treat several cancers. However, they are also toxic to normal cells (cytotoxic), particularly cells that divide frequently, such as those in the gastrointestinal tract, bone marrow, testicles and ovaries, which can cause loss of fertility. Most of the alkylating agents are also carcinogenic. Hyperthermia is especially effective at enhancing the effects of alkylating agents. |
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